Evidence map›Paper›PMID 42502703›Full record

ArticleBone reports2026

Persistent postnatal IGF2 expression alters adult skeletal architecture in

Shady Younis, Anika Shimonty, Samantha Perez-Menendez, Xiaomeng You, Sruthi M Sridevan, Soha Ben-Tahar, Harper Andrews, Sandra Shefelbine, Leif Andersson, Julia F Charles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shady YounisDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Anika ShimontyDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Samantha Perez-MenendezDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaomeng YouDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sruthi M SridevanDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Soha Ben-TaharDepartment of Bioengineering, Northeastern University, Boston, USA.
Harper AndrewsDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sandra ShefelbineDepartment of Bioengineering, Northeastern University, Boston, USA.
Leif AnderssonDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Julia F CharlesDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Marie Demay · 2019 to 2026
$7.4M
NIAMS NIH HHS P30 AR075042
6 · The paper itself

Abstract

Background: IGF2 is an imprinted growth factor essential for fetal development. A single nucleotide variation at a conserved ZBED6 binding site within Methods: We studied 13-week-old male and female Results: Conclusions: Post-natal IGF2 expression alters the adult murine skeleton by augmenting longitudinal growth and cortical accrual and inducing female-specific trabecular gains, with selective decrements in material properties. These data establish IGF2 as a regulator of postnatal bone architecture and mechanics and extend the functional scope of the conserved ZBED6-IGF2 regulatory axis to the skeleton.

Indexed as

Bone growthBone microarchitecture and biomechanicsInsulin-like growth factor 2 (IGF2)Sex differences in boneZBED6–IGF2 axis

Identifiers

PMID42502703
PMCPMC13400284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.