Evidence map›Paper›PMID 42502695›Full record

ArticleAdvances in ophthalmology practice and research

The association study between

Xinyu Wang, Jianxin Liu, Yukai Gong, Chunchun Yang, Yin Yang, Liang Zou, Yi Shi, Xianyan Qin, Lingxi Jiang

Abstract read
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In one paragraph

Article in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyu WangSchool of Food and Biological Engineering, Chengdu University, Chengdu, China.
Jianxin LiuSchool of Food and Biological Engineering, Chengdu University, Chengdu, China.
Yukai GongSchool of Food and Biological Engineering, Chengdu University, Chengdu, China.
Chunchun YangSchool of Food and Biological Engineering, Chengdu University, Chengdu, China.
Yin YangDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Liang ZouSchool of Food and Biological Engineering, Chengdu University, Chengdu, China.
Yi ShiGenetic Diseases Key Laboratory of Sichuan Province, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xianyan QinGenetic Diseases Key Laboratory of Sichuan Province, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lingxi JiangGenetic Diseases Key Laboratory of Sichuan Province, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purposes: Myopia, in particular high myopia (HM), is a major global ocular disorder and genetic factors playing a crucial role in its development. This study aimed to shed light on the genetic association between candidate single nucleotide polymorphisms (SNPs) and HM, offering insights into the mechanisms underlying HM. Methods: This case-control study involves 1008 unrelated Han Chinese participants, including 508 HM patients and 500 healthy controls. Eleven candidate SNPs that were previously linked to refractive errors in other populations were genotyped using multiplex polymerase chain reaction and high-throughput sequencing. We analyzed the associations between SNPs and HM under five genetic models, adjusting for age and sex. Ocular biometrics, such as axial length (AL) and refractive error, were correlated with the significant SNPs identified. We conducted functional annotation of the target SNP using bioinformatic tools. In addition, a form-deprivation myopia mouse model was employed to validate the role of the candidate gene through Western blot analysis of retinal proteins. Results: Among the 11 SNPs analyzed, rs17036350 in the Mechanistic Target of Rapamycin Kinase ( Conclusions: This study suggested that rs17036350 within

Indexed as

Axial lengthHan ChineseHigh myopiaMTOR

Identifiers

PMID42502695
PMCPMC13400861

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.