Evidence map›Paper›PMID 42502606›Full record

ArticleBiodesign research2026

Cellulose saccharification to alleviate CCR of xylose for enhanced 1, 2, 4-butanetriol production.

Shengji Li, Lisha Qin, Mengyue Ge, Yao Zuo, Mengyang Li, Sheng Xu, Xin Wang, Kequan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biodesign research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengji LiState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Lisha QinState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Mengyue GeState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Yao ZuoState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Mengyang LiState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Sheng XuState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Xin WangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.
Kequan ChenState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2,4-Butanetriol (BT) is a valuable polyol with applications in pharmaceuticals, materials, and military sectors. BT biosynthesis primarily uses xylose as substrate, with glucose supporting cell growth. However, glucose-mediated carbon catabolite repression (CCR) suppresses xylose assimilation, limiting BT production. This study aimed to investigate the impact of glucose on xylose-driven BT production in dual-carbon-source utilization and to develop a cellulose-based simultaneous saccharification and fermentation (SSF) strategy for enhanced glucose management, thereby alleviating CCR and improving BT yields. Heterologous BT biosynthesis pathways were introduced into

Indexed as

1,2,4-ButanetriolCarbon catabolite repressionDual-carbon-source utilizationSimultaneous saccharification and fermentation

Identifiers

PMID42502606
PMCPMC13400368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.