ReviewCureus2026
Impact of Integrated Exercise Interventions on Muscle Mass and Functional Outcomes in Patients With Decompensated Liver Cirrhosis and Sarcopenia: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia is a common and serious complication in patients with decompensated liver cirrhosis and is linked with reduced muscle mass, impaired functional capacity, poor physical performance, and decreased quality of life. Exercise-based rehabilitation and nutritional interventions have emerged as important non-pharmacological approaches for improving clinical and functional outcomes in this population. This comprehensive analysis sought to appraise the outcome of integrated exercise training programs on muscle mass, functional capacity, and quality of life in sarcopenic individuals with decompensated liver cirrhosis. There was an extensive search of the literature using PubMed, Google Scholar, Scopus, ScienceDirect, and Web of Science, published between 2012 and 2026. Randomized controlled trials (RCTs), clinical trials, observational studies, cross-sectional studies, and meta-analyses focusing on exercise, rehabilitation, and nutritional interventions were included. Risk of bias was checked using the Risk of Bias 2 (RoB 2) tool and the Appraisal Tool for Cross-Sectional Studies (AXIS) according to the study design. A total of 10 studies were found. Findings demonstrated that integrated exercise interventions, in addition to aerobic workouts, resistance training, balance training, and home-based rehabilitation programs, significantly enhance muscle strength, functional performance, aerobic capacity, body composition, and health-related quality of life. Nutritional interventions, such as branched-chain amino acid supplementation, also showed positive effects on muscle mass and maintenance of liver function. Most of the studies demonstrated moderate to high caliber with minimal potential for bias. The review concludes that integrated exercise training programs are safe and effective for increasing muscle mass, functional capacity, and quality of life for sarcopenic individuals with decompensated liver cirrhosis. Combined rehabilitation and nutritional strategies may play a vital part in the multidisciplinary management of cirrhosis-associated sarcopenia.
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Registered trials
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