Evidence map›Paper›PMID 42502504›Full record

ArticleClinical case reports2026

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report.

Soheil Roshanzamiri, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab Evini, Faraz Zandiyeh, Babak Mostafazadeh

Abstract read
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In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Soheil RoshanzamiriToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0001-8193-5649
Mitra RahimiToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-8785-8207
Shahin ShadniaToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
Peyman Erfantalab EviniToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
Faraz ZandiyehToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
Babak MostafazadehToxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-4872-9610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non-prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug-drug interaction, requiring a cautious assessment of causality.

Indexed as

case reportencephalopathyintracranial hypertensionisotretinoinneurotoxicityrizatriptan

Identifiers

PMID42502504
PMCPMC13401211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.