ArticleBiomaterial investigations in dentistry2026
Effect of graphene-based intracanal medicament on push-out bond strength of different endodontic sealers in root canal dentin - an in vitro study.
Article in Biomaterial investigations in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Graphene-based hydrogels incorporating antimicrobial agents, such as allicin and silver nanoparticles, offer potential therapeutic benefits. This study aimed to evaluate the effect of an allicin-incorporated graphene oxide-silver nanoparticle hydrogel on the push-out bond strength of endodontic sealers and the influence of different removal protocols. Materials and methods: A total of 60 extracted human single-rooted teeth were prepared to F3 size protaper and irrigated with 3% sodium hypochlorite and 17% Ethylenediaminetetraacetic Acid (EDTA) The experimental hydrogel (allicin + graphene oxide + silver nanoparticles in 2% sodium alginate base) was placed in all canals and incubated for 7 days. Specimens were randomised by sealer type (AH Plus, Mineral Trioxide Aggregate (MTA) Fillapex, Sealapex) and removal protocol: syringe irrigation, passive ultrasonic irrigation (PUI), or XP-Endo Finisher activation. Push-out bond strength was measured using a universal testing machine. A subset of specimens ( Results: Push-out bond strength was significantly influenced by both sealer type and removal protocol ( Conclusion: The allicin-incorporated graphene oxide-silver nanoparticle hydrogel did not compromise the push-out bond strength of the evaluated endodontic sealers when appropriate medicament removal protocols were employed. PUI and XP-Endo Finisher activation effectively facilitated hydrogel removal and maintained sealer adhesion, supporting the potential use of this material as an intracanal medicament.
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