Evidence map›Paper›PMID 42502456›Full record

ArticleCase reports in hematology2026

Severe Folate Deficiency Mimicking Myelodysplastic Syndrome/Acute Myeloid Leukemia: A Case Report.

Scott Potter, Margaret Williams, Timothy M Hanley

Abstract read
In one paragraph

Article in Case reports in hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Scott PotterDepartment of Pathology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.
Margaret WilliamsDepartment of Pathology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0000-0001-6031-1837
Timothy M HanleyDepartment of Pathology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0000-0002-6253-6850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Folate deficiency is common and often asymptomatic, but severe cases can cause megaloblastic anemia. Rarely, it presents with pancytopenia and bone marrow changes resembling myelodysplastic syndrome/neoplasm (MDS) and/or acute myeloid leukemia (AML), complicating diagnosis and management. We present a case of a patient with severe folate deficiency, in the setting of normal vitamin B12 levels, who presented with hematologic and bone marrow findings initially suggestive of MDS/AML that resolved with folate supplementation. This case highlights that the clinical and morphologic findings associated with severe folate deficiency can closely resemble those of high-risk MDS or MDS/AML. Careful diagnostic evaluation, including nutritional assessment, is essential to avoid the misclassification of reversible nutritional deficiencies as myeloid neoplasms requiring cytotoxic therapy.

Indexed as

acute myeloid leukemia (AML)case reportfolate deficiencymegaloblastic anemiamyelodysplastic syndrome/neoplasm (MDS)

Identifiers

PMID42502456
PMCPMC13400839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.