Evidence map›Paper›PMID 42502434›Full record

ArticleInternational journal of pharmaceutics: X2026

The effect of varying water volumes on in vivo dissolution and gastric emptying of highly soluble caffeine and lesser soluble theobromine containing capsules.

Linus Großmann, Johanna Cyrus, Stefan Senekowitsch, Toni Wildgrube, Marie-Luise Kromrey, Werner Weitschies, Philipp Schick, Michael Grimm

Abstract read
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In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linus GroßmannUniversity of Greifswald, Institute of Pharmacy, Dep. of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Johanna CyrusMartin-Luther-University Halle-Wittenberg, Institute of Pharmacy, Dep. of Pharmaceutical Technology, 06099 Halle, Germany.
Stefan SenekowitschUniversity Medicine Rostock, Institute of Pharmacology and Toxicology, Schillingallee 70, 18057 Rostock, Germany.
Toni WildgrubeUniversity of Greifswald, Institute of Pharmacy, Dep. of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Marie-Luise KromreyUniversity Medicine Carl Gustav Carus, Institute of Diagnostic and Interventional Radiology, Fetscherstraße 74, 01307 Dresden, Germany.
Werner WeitschiesUniversity of Greifswald, Institute of Pharmacy, Dep. of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Philipp SchickUniversity of Greifswald, Institute of Pharmacy, Dep. of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Michael GrimmUniversity of Greifswald, Institute of Pharmacy, Dep. of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of co-administered water volume on the intragastric dissolution and the systemic exposure of drugs taken under fed conditions remains clinically relevant, particularly for drug substances with limited aqueous solubility. This secondary pharmacokinetic analysis, based on a previously published MRI study (

Indexed as

CaffeineGastric EmptyingIn Vivo DissolutionMagenstrasseOral Drug AbsorptionSalivaTheobromine

Identifiers

PMID42502434
PMCPMC13400285

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.