Evidence map›Paper›PMID 42502413›Full record

ArticleiScience2026

Systematic review and network meta-analysis of non-pharmacological interventions for inadequate perfusion in hypothermic circulatory arrest.

Lingda Meng, Zhijing Wei, Xuan Jiang, Chunmao Lu, Qin Fang, Peng Yu, Zhiwei Zhang, Enyi Shi, Tianxiang Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lingda MengDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Zhijing WeiInstitute of Trauma Center, First Affiliated Hospital, China Medical University, Shenyang, China.
Xuan JiangDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Chunmao LuDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Qin FangDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Peng YuDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Zhiwei ZhangDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Enyi ShiDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.
Tianxiang GuDepartment of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This network meta-analysis aimed to compare different non-pharmacological interventions for insufficient perfusion after hypothermic circulatory arrest, a key technique in aortic arch surgery. The authors retrieved and analyzed 60 eligible studies from four databases up to July 2025. The results showed that moderate hypothermia combined with specific cerebral perfusion strategies achieved better overall outcomes. Moderate hypothermia generally improved multiple clinical indicators without affecting several complications, and different perfusion approaches and cannulation methods had comparable effects. This work helps surgeons select optimal interventions and improve patient prognosis after aortic arch surgery.

Indexed as

hypothermic circulatory arrestinadequate perfusionnetwork meta-analysisnon-pharmacological interventions

Identifiers

PMID42502413
PMCPMC13400770

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.