LRMDA promotes intestinal mucosal barrier integrity and limits colitis and colon cancer.

Liping Yang, Yuyao Guo, Bikun Xiao, Di Wang, Bo Zhong, Zhi-Dong Zhang, Dandan Lin

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liping YangCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Yuyao GuoCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Bikun XiaoCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Di WangZhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Bo ZhongCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Zhi-Dong ZhangCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Dandan LinCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal homeostasis relies on the integrity of the mucosal barrier, whose disruption contributes to inflammatory bowel disease (IBD), enteric infection, and colorectal cancer (CRC). Here, we report that leucine-rich melanocyte differentiation-associated protein (LRMDA) is markedly downregulated in inflamed mucosal tissues from patients with IBD and in colorectal tumor tissues. Genetic ablation of LRMDA in mice exacerbates dextran sulfate sodium (DSS)-induced colitis, enhances colorectal tumorigenesis in both azoxymethane (AOM)/DSS and AOM/

Indexed as

colitiscolon cancerintestinal barrier integrityLRMDAmucin

Identifiers

PMID42502405

DOI10.1016/j.isci.2026.116785

PMCPMC13400768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.