Evidence map›Paper›PMID 42502390›Full record

ArticleiScience2026

Single-cell transcriptomics identifies a p21-activated kinase important for survival of the zoonotic parasite

Oliver Puckelwaldt, Svenja Gramberg, Sagar Ajmera, Janine Koepke, Jamal Shamsara, Christos Samakovlis, Peter Kolb, Simone Haeberlein

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oliver PuckelwaldtInstitute of Parasitology, Justus Liebig University Giessen, Giessen, Germany.
Svenja GrambergInstitute of Parasitology, Justus Liebig University Giessen, Giessen, Germany.
Sagar AjmeraInstitute of Parasitology, Justus Liebig University Giessen, Giessen, Germany.
Janine KoepkeCardio-Pulmonary Institute (CPI), Giessen, Germany.
Jamal ShamsaraDepartment of Pharmaceutical Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Christos SamakovlisCardio-Pulmonary Institute (CPI), Giessen, Germany.
Peter KolbDepartment of Pharmaceutical Chemistry, Philipps-Universität Marburg, Marburg, Germany.
Simone HaeberleinInstitute of Parasitology, Justus Liebig University Giessen, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knowledge on the cell types and cell-specific gene expression of multicellular pathogens facilitates drug discovery and allows gaining a deeper understanding of pathogen biology. By utilizing single-cell RNA sequencing (scRNA-seq), we analyzed 19,581 cells of a globally prevalent parasitic flatworm, the liver fluke

Indexed as

drug targetFasciola hepaticaflatwormsliver flukesp21-activated kinasescRNASeqsingle-cell transcriptomicsstem cellsTRPM

Identifiers

PMID42502390
PMCPMC13400776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.