Evidence map›Paper›PMID 42502379›Full record

ArticleiScience2026

Planar cell polarity complex internalization is dependent on Celsr1

Sarah G Latario, Thomas Saba, Brandon Trejo, William Giang, Stephanie E Zimmer, Danelle Devenport, Sara N Stahley

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah G LatarioBiomedical Sciences Graduate Program, Penn State College of Medicine, Hershey, PA, USA.
Thomas SabaBiomedical Sciences Graduate Program, Penn State College of Medicine, Hershey, PA, USA.
Brandon TrejoDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
William GiangDepartment of Dermatology, Penn State College of Medicine, Hershey, PA, USA.
Stephanie E ZimmerDepartment of Dermatology, Penn State College of Medicine, Hershey, PA, USA.
Danelle DevenportDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Sara N StahleyDepartment of Dermatology, Penn State College of Medicine, Hershey, PA, USA.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Multiscale coordination of planar cell polarityR01AR066070 · NIAMS · PRINCETON UNIVERSITY · PI DEVENPORT, DANELLE N · 2015 to 2025
$5.7M
Cell-cycle control of cell polarity in epidermal patterning and differentiationR01AR068320 · NIAMS · PRINCETON UNIVERSITY · PI Danelle N Devenport · 2016 to 2026
$3.8M
Cadherin regulation of planar polarityR35GM150921 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Sara N Stahley · 2023 to 2026
$1.6M
Celsr1-mediated planar cell polarity: defining the adhesive interface and mechanisms of asymmetryF32AR071764 · NIAMS · PRINCETON UNIVERSITY · PI STAHLEY, SARA N · 2017 to 2019
$178k
NIAMS NIH HHS F32 AR071764NIAMS NIH HHS R01 AR066070NIAMS NIH HHS R01 AR068320NIGMS NIH HHS R35 GM150921NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Planar cell polarity (PCP) coordinates collective cell polarity along a tissue plane through the asymmetric localization of junctional complexes comprised of core transmembrane proteins: Celsr1, Fz6, and Vangl2. Basal cells of embryonic mouse epidermis undergo numerous cell divisions to support the developing tissue while also maintaining tissue-level polarity. To achieve this, junctional PCP complexes are selectively co-internalized by the dividing cell, facilitating the restoration of tissue polarity upon mitotic exit. In

Indexed as

cell adhesiondimerizationjunctional traffickingmitosisplanar cell polaritytrans-endocytosis

Identifiers

PMID42502379
PMCPMC13400783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.