Evidence map›Paper›PMID 42502377›Full record

ArticleiScience2026

Causal AI digital twin for bioprocess bottleneck diagnosis via metabolic flexibility and rigidification maps.

Changman Kim, Hyeongwoo Choi, Dukwoo Kim

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Changman KimDepartment of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61188, Republic of Korea.
Hyeongwoo ChoiDepartment of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61188, Republic of Korea.
Dukwoo KimDepartment of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61188, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing underperforming non-model microbial cultures remains difficult. To address this, we developed an intervention-aware genome-informed digital twin with interpretable flexibility features, explainable learning, and causal-structure discovery to convert sparse anchors into actionable diagnostic artifacts. We grew

Indexed as

bottleneck diagnosiscausal discoverydigital twinexplainable AIflux variability analysisgenome-scale metabolic modelmetabolic flexibilityregime shiftsSHAPStenotrophomonas maltophilia

Identifiers

PMID42502377
PMCPMC13400960

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.