Evidence map›Paper›PMID 42502361›Full record

ArticleJID innovations : skin science from molecules to population health2026

Demographic factors associated with skin barrier function in a large population-based study.

Katrina Abuabara, Benjamin Stroebel, Shreya Sreekantaswamy, Richard W Kim, Linda Zukley, Noreen Karim, Robert H Rice, Blythe P Durbin-Johnson, David M Rocke, Theodora Mauro

Abstract read
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In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katrina AbuabaraDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Benjamin StroebelDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Shreya SreekantaswamyDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Richard W KimSchool of Medicine, University of California, San Francisco, San Francisco, California, USA.
Linda ZukleyBaltimore Longitudinal Study of Aging, Baltimore, Maryland, USA.
Noreen KarimUniversity of California, Davis, Davis, California, USA.
Robert H RiceUniversity of California, Davis, Davis, California, USA.
Blythe P Durbin-JohnsonUniversity of California, Davis, Davis, California, USA.
David M RockeUniversity of California, Davis, Davis, California, USA.
Theodora MauroDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.

Funding

Pathogenesis and Therapy of Ichthyosis in Disorders of Lipid MetabolismR01AR061106 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2022
$3.3M
QE-HF-X Mass SpectrometerS10OD026918 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2020 to 2020
$600k
A pilot trial of skin barrier restoration to reduce systemic inflammationR21AR082620 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABUABARA, KATRINA ELAINE · 2024 to 2025
$540k
BLRD VA I01 BX006094NIAMS NIH HHS R01 AR061106NIAMS NIH HHS R21 AR082620NIH HHS S10 OD026918
6 · The paper itself

Abstract

The skin plays a vital role in homeostasis, but there are conflicting data on skin barrier function-associated factors. We evaluated the relationship between participant characteristics and barrier function measures (baseline transepidermal water loss, barrier integrity [number of tape strips required to increase transepidermal water loss by 4 times baseline], dynamic barrier function [area under the curve of number of tape strips plotted against repeated transepidermal water loss measurements], and barrier recovery [percentage recovery in transepidermal water loss 24 hours after tape stripping]) in 286 participants aged 32-97 years in the Baltimore Longitudinal Study of Aging cohort. Multivariable analysis indicated that older age, female sex, Black race, and higher body mass index were associated with at least 1 measure of better barrier function: older age was associated with better dynamic barrier function (beta = -0.071,

Indexed as

AgingPopulation studyProteomicsSkin barrier

Identifiers

PMID42502361
PMCPMC13400667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.