Evidence map›Paper›PMID 42502320›Full record

ArticleBioactive materials2026

Self-assembling biomimetic peptide hydrogel regulates tissue homeostasis to promote repair of persistent corneal epithelial defects.

Mengyuan Shan, Yinghao Ding, Ping Lu, Fuqi Deng, Le Chang, Qin Zhou, Xinyu Li, He Tian, Qimiao Wang, Yi Dong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengyuan ShanNankai University Eye Institute, School of Medicine, Nankai University, Tianjin, 300071, China.
Yinghao DingZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, NHC Key Laboratory of Clinical Nutrition and Intervention, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Ping LuTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Fuqi DengTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Le ChangTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Qin ZhouTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Xinyu LiNankai University Eye Institute, School of Medicine, Nankai University, Tianjin, 300071, China.
He TianTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Qimiao WangTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Yi DongTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.
Zhimou YangZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, NHC Key Laboratory of Clinical Nutrition and Intervention, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Jiaqing WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Yan WangTianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, 300020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent corneal epithelial defects (PCED) remain a significant clinical challenge due to rapid tear turnover, blinking-induced shear stress, and a protease-rich ocular surface that limit the efficacy of soluble bioactive factors. We report a dual-functional self-assembling peptide hydrogel, mIGF-Gel (Biotin-

Indexed as

Corneal epithelial regenerationInsulin-like growth factor 1 (IGF-I)PeptidePersistent epithelial defectSelf-assembly

Identifiers

PMID42502320
PMCPMC13400331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.