Advanced lyophilized mesenchymal stem cell-conditioned medium formulation improves therapeutic efficacy in skin wound repair.

Xinjiani Chen, Bailei Li, Wenxue Gu, Mingjuan Li, Zhen Zhang

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Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Xinjiani ChenDepartment of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.ORCID https://orcid.org/0009-0000-3717-9903

Bailei LiDepartment of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China.

Wenxue GuDepartment of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China.

Mingjuan LiDepartment of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.

Zhen ZhangDepartment of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China.ORCID https://orcid.org/0000-0001-8057-7624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The secretome of human umbilical cord mesenchymal stem cells (hUC-MSCs) represents a promising cell-free therapeutic approach for wound healing because of its rich composition of bioactive factors that promote tissue repair. However, the clinical translation of secretome-based therapies is hindered by the instability of its bioactive components during storage. To address this challenge, we developed a lyophilization strategy using cryoprotectants to produce a stable, powdered form of hUC-MSC-conditioned medium (CM). Our results demonstrated that the lyophilized CM (Lyo-CM), particularly when formulated with specific cryoprotectants, maintained excellent bioactivity of CM while showing superior reproducibility and stability. Furthermore, both

Indexed as

conditioned mediumcryoprotectantslyophilizationmesenchymal stem cellsskin wound healing

Identifiers

PMID42502267

DOI10.1093/rb/rbag140

PMCPMC13401446

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