ArticleMacromolecular bioscience2026
Rational Design of Amphiphilic Copillar[5]arene Conjugates for Enhanced Nanodelivery: Synthesis, Nanoparticle Optimization, and In Vitro Biocompatibility.
Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A single component, synthetically tunable amphiphilic copillar[5]arene platform was developed as a modular supramolecular scaffold for therapeutic nano-delivery. Structural variation of the hydrophobic segment, together with PEG functionalization, enables precise control over amphiphilicity, self-assembly, and host-guest behavior, thereby providing a single-component platform that addresses the multicomponent formulation challenges commonly associated with drug delivery systems. Notably, the hydrophobic and electron-rich cavity efficiently assisted in encapsulating a hypoxia-activatable self-immolative linker-based guest, highlighting the potential of this system for encapsulating therapeutically relevant cargos and enabling tumor-selective release. In Vitro studies further demonstrated efficient cellular uptake and negligible toxicity of the blank nanoformulation, validating its suitability as a delivery vehicle. This work establishes copillar[5]arene nano-assemblies as a versatile and synthetically tailorable suprascaffold that combines structural programmability, cargo compatibility, and biological safety, thereby providing a promising platform for precision cancer nanomedicine and advanced drug delivery applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.