Evidence map›Paper›PMID 42502239›Full record

ReviewClinical pharmacology and therapeutics2026

Navigating the Prescription Drug Information System.

Irina V Wang, Courtney Davis, Robin Forrest, Avi Cherla, Maximilian Siebert, Janice Cowden, Sophia Walker, Tamar Krishnamurti, Florence T Bourgeois, Steven Woloshin and 2 more

Abstract readReview
In one paragraph

Review in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irina V WangPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.ORCID 0009-0008-3008-300X
Courtney DavisPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.
Robin ForrestPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.
Avi CherlaPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.
Maximilian SiebertHarvard-MIT Center for Regulatory Science, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4385-5773
Janice CowdenPatient Advocate, North Port-Sarasota, Florida, USA.
Sophia WalkerPatient Partner, Cambridge, Massachusetts, USA.ORCID 0009-0002-9205-1552
Tamar KrishnamurtiDivision of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3416-2230
Florence T BourgeoisPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.ORCID 0000-0001-7798-4560
Steven WoloshinPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.
Anita K WagnerPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.
Huseyin NaciPharmaceutical Policy Lab, LSE Health, The London School of Economics and Political Science, London, UK.ORCID 0000-0002-7192-5751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information on new prescription drugs is increasingly complex and fragmented, posing challenges for healthcare professionals, patients, and payers. Clinicians require concise, actionable guidance to support prescribing decisions, while patients seek to balance benefits and harms when making decisions aligned with their treatment goals. Payers need comparative effectiveness data to inform coverage decisions that shape access and resource allocation. However, inadequacies in drug information communication often lead to overestimation of benefits and underestimation of harms. In this White Paper, we explore how information about newly approved drugs is generated, disseminated, and interpreted. We examine the information needs of healthcare professionals, patients, and payers and the influence of regulatory standards on available evidence. Focusing on regulated communication channels, such as prescription drug labeling, medication guides, and clinical trial snapshots, we highlight the foundational role of regulatory agencies in setting evidence standards and legitimizing drug information. We also consider alternative information sources, including pharmaceutical advertising, which coexist with regulated content. Against a backdrop of increasing uncertainty of drug approval evidence, we identify documented principles that regulators can adopt to meet drug information needs. Recommendations for improvements aim to better serve patients, support clinical decision making, and promote ethical healthcare resource allocation. While centered on the US context, the paper draws parallels with the European information landscape.

Indexed as

Drug Information ServicesPrescription DrugsDrug ApprovalDrug LabelingHumansUnited StatesPrescription Drugs

Identifiers

PMID42502239
PMCPMC13401667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.