ArticleCPT: pharmacometrics & systems pharmacology2026
DDIapp-A Web-Based Application for Static Drug-Drug Interaction Assessment.
Article in CPT: pharmacometrics & systems pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
In this work we describe the development of a web-based application for static drug-drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models for the assessment of enzyme inhibition, enzyme induction, and transporter inhibition at intestinal, hepatic, and renal levels. In addition, a "net effect" model estimates the combined impact of inhibition and induction on victim drug exposure, expressed as the area under the curve ratio (AUCR). Matrix-specific approaches for estimating unbound fractions in microsomes and hepatocytes (f
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