ReviewOncogene2026
tRNA-derived small RNAs in tumor microenvironment remodeling: From mechanistic insights to therapeutic perspectives.
Review in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Transfer RNA-derived small RNAs (tsRNAs) represent an emerging class of non-coding RNAs involved in gene expression and cellular homeostasis. Growing evidence suggests that tsRNAs contribute to tumor initiation and progression, in part by reshaping the tumor microenvironment (TME). This review systematically summarizes the biogenesis and molecular mechanisms of tsRNAs and discusses how they regulate key TME-associated processes, including immune cell function, metabolic reprogramming, angiogenesis, and extracellular vesicle-mediated intercellular communication. We further examine their clinical relevance, focusing on circulating biomarkers, therapeutic targeting and delivery strategies, as well as current limitations for translation. In the tumor microenvironment, tRNA-derived small RNAs regulate multiple interconnected processes, including immunosuppression, metabolic reprogramming, angiogenesis, and extracellular vesicle-mediated cell-cell communication, thereby contributing to tumor progression.
Indexed as
Identifiers
42502104What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.