Evidence map›Paper›PMID 42501516›Full record

ReviewDrug and alcohol dependence2026

Mapping and measuring addiction recovery: Recommended protocols through the PHENX toolkit.

John F Kelly, Sarah Zemore, Corrie L Vilsaint, Tamara Haegerich, Wayne Huggins, Cataia Ives, Christine Hill, Carol M Hamilton, Denise Vidot, Johannes Thrul and 4 more

Abstract readReview
In one paragraph

Review in Drug and alcohol dependence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

John F KellyRecovery Research Institute, Massachusetts General Hospital, Psychiatry, Boston, MA, USA; Harvard Medical School, USA. Electronic address: jkelly11@mgh.harvard.edu.
Sarah ZemoreAlcohol Research Group, Emeryville, CA, USA.
Corrie L VilsaintIndependent Consultant, MA, USA.
Tamara HaegerichUniversity of Illinois at Chicago, Chicago, IL, USA.
Wayne HugginsRTI International, Durham, NC 27709, USA.
Cataia IvesRTI International, Durham, NC 27709, USA.
Christine HillRTI International, Durham, NC 27709, USA.
Carol M HamiltonRTI International, Durham, NC 27709, USA.
Denise VidotGlobal Cannabis and Psychedelics Research Collaboratory, University of Miami School of Nursing and Health Studies, USA.
Johannes ThrulJohns Hopkins Bloomberg School of Public Health, USA.
Ryan McNeilYale School of Medicine, USA.
Christian HopferUniversity of Colorado, USA.
Amanda BuntingNew York University, Grossman School of Medicine, USA.
Anne BuuUniversity of Texas, Houston, School of Public Health, USA.

Funding

Establishing the PhenX Toolkit as a Biomedical KnowledgebaseU24HG012556 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI Carol Marie Hamilton · 2022 to 2026
$8.7M
Mentoring in Patient-Oriented Addiction ResearchK24AA022136 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI KELLY, JOHN F. · 2014 to 2023
$1.8M
NHGRI NIH HHS U24 HG012556NIAAA NIH HHS K24 AA022136
6 · The paper itself

Abstract

backgroundAddiction "recovery" has served as a positive conceptual basis for major public health frameworks, communication strategies, and policies. With greater research interest and increasing explication of the recovery construct a multitude of measures have emerged, prompting a need to reach consensus on recommendations to enable better data harmonization and cross-study syntheses. The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (www.phenxtoolkit.org) is a freely accessible catalog of validated protocols designed to promote data comparability across clinical, epidemiological, and genomic research, yet contained no recovery-specific measures.

methodIn 2024, a Substance Use and Recovery Working Group (SURWG) followed a well-established and detailed PhenX consensus process to identify and recommend protocols suitable for recovery research. Protocols were chosen based on criteria including recovery specificity, brevity, psychometrics, scoring simplicity, and non-proprietary access. The broader scientific community (12 national/regional organizations) provided feedback (respondent N = 86) on the SURWG's preliminary recommendation which was incorporated into final decisions.

resultsIn 2025, the PhenX Toolkit released 15 new recommended protocols across three broad recovery elements: 1. Biopsychological (post-acute withdrawal; craving), 2. Socio-ecological (social relationships;social network characteristics; substance use goal; recovery identity; recovery capital), 3. Treatment and recovery services (Treatment and Recovery Services Use; Satisfaction; and Happiness in Recovery; Mutual-Help).

conclusionsThis PhenX Toolkit SURWG process resulted in a new Substance Use Recovery Specialty Collection of recommended protocols with specific multidimensional applicability. As such, they provide the field with pre-vetted tools that researchers can employ with some confidence to enhance empirical efficiency and return on national research investment.

Indexed as

Behavior, AddictiveSubstance-Related DisordersHumans

Identifiers

PMID42501516
PMCPMC13477208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.