Evidence map›Paper›PMID 42501327›Full record

ReviewSTAR protocols2026

A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.

Mir A Raza, Andrew Folz, Daniella B Victorino, Zhuo Xing, Xu-Qiao Chen, Xinxin Zuo, Leah K Borden, Marie-Claude Potier, William Mobley, Mara Dierssen and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mir A RazaDepartment of Biology, College of Arts & Sciences, University of Dayton, Dayton, OH 45469, USA.
Andrew FolzDepartment of Biology, Indiana University, Indianapolis, IN 46202, USA.
Daniella B VictorinoInstitut du Cerveau - Paris Brain Institute - ICM, CNRS, APHP, Hôpital de La Pitié Salpêtrière, Inserm, Sorbonne Université, Paris, France.
Zhuo XingThe Children's Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Xu-Qiao ChenDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Xinxin ZuoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Leah K BordenDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Alana Down Syndrome Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Marie-Claude PotierInstitut du Cerveau - Paris Brain Institute - ICM, CNRS, APHP, Hôpital de La Pitié Salpêtrière, Inserm, Sorbonne Université, Paris, France.
William MobleyDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Mara DierssenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, University Pompeu Fabra, Barcelona, Biomedical Research Networking Center for Rare Diseases (CIBERER), 28036 Barcelona, Spain.
Masaharu HiratsukaChromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
Yasuhiro KazukiChromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
Kristy WelshhansDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA; Carolina Autism and Neurodevelopment (CAN) Research Center, University of South Carolina, Columbia, SC 29208, USA.
Michelle Maugham-MacanSchool of Health, University of the Sunshine Coast, Sippy Downs QLD 4556, Queensland, Australia.
Antonella TramutolaDepartment of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Eitan OkunThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Ramat Gan, Ramat Gan 5290002, Israel.
Roger ReevesDepartment of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Randall J RoperDepartment of Biology, Indiana University, Indianapolis, IN 46202, USA.
Y Eugene YuThe Children's Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Yann HéraultUniversité of Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR7104 U1258, 1 Rue Laurent Fries, 67404 Illkirch, France; Université of Strasbourg, CNRS, INSERM, PHEN-ICS, UAR2062, US66, Illkirch, France; CNRS, CELPHEDIA Core, UAR2052, US66, Villejuif, France.
Victor L J TybulewiczThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Elizabeth M C FisherDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Aaron SathyanesanDepartment of Biology, College of Arts & Sciences, University of Dayton, Dayton, OH 45469, USA; Department of Electrical & Computer Engineering, School of Engineering, University of Dayton, Dayton, OH 45469, USA. Electronic address: asathyanesan1@udayton.edu.

Funding

Mechanisms of Down syndrome-associated swallowing dysfunction in mouse modelsR01DC019735 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI NADINE P CONNOR, Tiffany Glass · 2022 to 2026
$3.4M
Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficitsR01HD109750 · NICHD · ROSWELL PARK CANCER INSTITUTE CORP · PI Eugene Yu · 2022 to 2026
$3.3M
Modifiers of Down Syndrome Co-occurring PhenotypesR01HD118475 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI ROPER, RANDALL J · 2025 to 2025
$1.3M
Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes.F32HL178155 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Leah K Borden · 2025 to 2026
$161k
NHLBI NIH HHS F32 HL178155NICHD NIH HHS R01 HD109750NICHD NIH HHS R01 HD118475NIDCD NIH HHS R01 DC019735Wellcome Trust CC2080
6 · The paper itself

Abstract

Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels. Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.

Indexed as

BehaviorDevelopmental biologyNeuroscienceNMGN Focused Collection

Identifiers

PMID42501327
PMCPMC13449384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.