Evidence map›Paper›PMID 42501230›Full record

ArticleNeuroscience bulletin2026

Decoding the Oxytocinergic and Behavioral Signatures of Milk Ejection.

Wei Xiao, Qian Zheng, Yang Wang, Ying Yuan, Yuge Chen, Tianxing Zheng, Yuzhu Chen, Yijia Gao, Bingrui Song, Bin Zhang and 7 more

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wei XiaoDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Qian ZhengState Key Laboratory of Brain-machine Intelligence, MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, 311121, China.
Yang WangState Key Laboratory of Brain-machine Intelligence, MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, 311121, China.
Ying YuanDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yuge ChenDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Tianxing ZhengDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, 310058, China.
Yuzhu ChenDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yijia GaoCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
Bingrui SongDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Bin ZhangDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0002-2597-0578
Liyao QiuDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0002-9105-9782
Linghui ZengKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, China.
Huan MaDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Colin H BrownFaculty of Biomedical Sciences, Centre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin, 9054, New Zealand.
Shumin DuanDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Gang PanState Key Laboratory of Brain-machine Intelligence, MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, 311121, China. gpan@zju.edu.cn.
Zhihua GaoDepartment of Neurology of Second Affiliated Hospital and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China. zhihuagao@zju.edu.cn.ORCID http://orcid.org/0000-0001-8603-0777

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxytocin-mediated milk ejection (ME) is pivotal to effective breastfeeding and reproductive health, yet behaviorally decoding and revealing neural mechanisms of ME remains challenging. Here, we combined in vivo calcium imaging and intramammary pressure recording to uncover the temporal connections between episodic activity of oxytocin neurons and ME in conscious lactating rats. Leveraging the coordinated behavioral responses of dams and pups, we developed a supervised machine learning framework (ME Decoder) to enable automated analyses of ME. Inspired by its interpretable features, we defined the activity-coupled dam-pup interactions (ADPI), manifested by pronounced kyphosis in dams, followed by pup treading and stretching, as the behavioral signatures of ME. By ME Decoder and ADPI analyses, we detected reduced ME but unaffected activity of oxytocinergic neurons after systemic blockade of oxytocin receptors. Our study uncovers the oxytocinergic and behavioral signatures of ME and provides a generalizable approach for further investigation.

Indexed as

Deep learning frameworkLactationMilk ejectionNeural pathwaysNeuronal activityOxytocin

Identifiers

PMID42501230

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.