Evidence map›Paper›PMID 42501225›Full record

ArticleNeuroscience bulletin2026

State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.

Wenlei Zhang, Xiaotian Wu, Chengjie Tang, Weicong Sang, Yujian Ye, Hong Gan, Tianzhen Chen, Ti-Fei Yuan, Rongwei Zhai, Haifeng Jiang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenlei Zhang *Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Xiaotian Wu *Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Chengjie TangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Weicong SangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Yujian YeShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Hong GanShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Tianzhen ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Ti-Fei YuanShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Rongwei ZhaiHainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China. zhairongwei@muhn.edu.cn.
Haifeng JiangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. dragonjhf@hotmail.com.
Zhi-Qi XiongCAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, 200031, China. xiongzhiqi@ion.ac.cn.
Min ZhaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. drminzhao@smhc.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ventral striatum (VS) is a promising target for deep brain stimulation (DBS) for the treatment of refractory psychiatric disorders. The therapeutic effects of DBS rely on altering neural activity within specific networks; however, the network-level oscillatory mechanisms underlying VS-DBS remain unclear. Here, in human subjects with DBS electrodes implanted in the VS and anterior limb of the internal capsule, electroencephalography recordings obtained during DBS ON and OFF conditions revealed a global suppression of theta activity. To isolate these effects specific to VS stimulation, we applied direct electrical stimulation to the VS in two rhesus monkeys while simultaneously recording intracranial local field potentials from the reward-network regions. High-frequency stimulation (HFS) of the VS elicited target-specific, current-dependent, state-dependent, and distributed modulation of theta activity, whose magnitude was related to effective connectivity. Overall, VS-HFS exerted state-dependent modulation of a theta-responsive subnetwork. These findings may help to elucidate the therapeutic mechanisms of VS-DBS.

Indexed as

Deep brain stimulationReward networkState-dependent modulationTheta oscillationsVentral striatum

Identifiers

PMID42501225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.