Evidence map›Paper›PMID 42501223›Full record

ArticleNeuroscience bulletin2026

Cocaine Hijacks the Npas4-dependent Somatostatin Ensembles in the mPFC to Mediate Attention.

Xutian Hou, Kunxiu Han, Feifei Wang, Changyou Jiang, Lan Ma, Tao Jin

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xutian Hou *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China.
Kunxiu Han *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China.
Feifei WangState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2351-6873
Changyou JiangState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China.
Lan MaState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China.
Tao JinState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, School of Basic Medical Sciences, Pharmacology Research Center, Fudan University, Shanghai, China. tjin17@fudan.edu.cn.ORCID http://orcid.org/0009-0003-0038-3523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cocaine disrupts the physiological function of the prefrontal cortex and impairs attention, short-term memory, and other cognitive functions. However, the specific cellular basis of maladaptation remains poorly understood. Here, using neuronal activity-dependent tagging, rabies retrograde tracing, electrophysiological recording, and behavioral analyses in mice, we show that a single injection of cocaine increases the recruitment of both the Npas4 transcription-dependent ensemble (N-RAM) and the N-RAM

Indexed as

AttentionCocainemPFCN-RAMSST-IN

Identifiers

PMID42501223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.