Evidence map›Paper›PMID 42501188›Full record

ArticleScience China. Life sciences2026

Histone lactylation inhibits Slc25a51 expression and thus promotes collagen dysregulation of pelvic organ prolapse through impairing mitochondrial NAD

Yong He, Cheng Liu, Bingshu Li, Shasha Hong, Jianming Tang, Guotao Huang, Lian Yang, Mao Chen, Shufei Zhang, Ya Xiao and 6 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yong He *Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Cheng Liu *Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bingshu LiDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Shasha HongDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jianming TangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Guotao HuangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Lian YangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Mao ChenDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Shufei ZhangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Ya XiaoDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jianfeng LiuDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Minqi NingDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Nuo JiangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Chunrong XiangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Shouqi HuangDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Li HongDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China. dr_hongli@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic organ prolapse (POP) is a common gynecological disorder severely affecting quality of life, characterized by extracellular matrix (ECM) disruption and metabolic dysregulation. Lactylation is a lactate-induced post-translational modification that regulates gene expression, but its role in POP remains unclear. Here, we demonstrate that enhanced glycolysis and lactate accumulation drive histone lactylation, which impairs mitochondrial function and collagen biosynthesis in POP. Furthermore, we identify histone acetyltransferase Kat7 as a key lactyltransferase that catalyzes H3K14 and H3K18 lactylation via its glutamate residue E508. Notably, H3K14la/H3K18la suppresses the expression of Slc25a51, a mitochondrial NAD

Indexed as

CollagenHistonesMitochondriaNADPelvic Organ ProlapseAnimalsFemaleFibroblastsGlycolysisHistone AcetyltransferasesHumansLactic AcidMiceProlineProtein Processing, Post-TranslationalCollagenHistone AcetyltransferasesHistonesLactic AcidNADProlinehistone lactylationKat7mitochondrial NAD+pelvic organ prolapseSlc25a51

Identifiers

PMID42501188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.