Evidence map›Paper›PMID 42501125›Full record

ArticleCalcified tissue international2026

Differential Effects of a First-in-Class IKK

Abdullah Al-Jeffery, Feier Zeng, Antonia Sophocleous, Silvia Marino, Marco Ponzetti, Mattia Capulli, Andrew Paul, Robin Plevin, Ann C M Fowles, Simon P Mackay and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdullah Al-JefferyDepartment of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, England, UK.
Feier Zeng *Department of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, England, UK.
Antonia Sophocleous *Department of Life Sciences, European University Cyprus, Nicosia, Cyprus.
Silvia MarinoDepartment of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, England, UK.
Marco PonzettiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Mattia CapulliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Andrew PaulStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0NR, Scotland, UK.
Robin PlevinStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0NR, Scotland, UK.
Ann C M FowlesDepartment of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, England, UK.
Simon P MackayStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0NR, Scotland, UK.
Nadia RucciDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Aymen I IdrisDepartment of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, England, UK. aymen.idris@sheffield.ac.uk.ORCID http://orcid.org/0000-0003-4327-5306

Funding

Cancer Research UK A9336Prostate Cancer UK PG12-27
6 · The paper itself

Abstract

IKK

Indexed as

Bone and BonesCancellous BoneI-kappa B KinaseProstatic NeoplasmsAnimalsCell Line, TumorHumansMaleMiceNF-kappa BOsteoblastsOsteoclastsPC-3 CellsSignal TransductionXenograft Model Antitumor AssaysCHUK protein, humanI-kappa B KinaseNF-kappa BBone metastasisIKKαNFkBOsteolysisProstate cancer

Identifiers

PMID42501125
PMCPMC13401539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.