Evidence map›Paper›PMID 42501066›Full record

ReviewXenotransplantation

A Review of Informed Consent for Porcine Islet Xenotransplantation to Treat Type 1 Diabetes.

Jennifer Kovalcik, Sheetal Mohanty, Mairead Higgins, Daniel J Hurst

Abstract readReview
In one paragraph

Review in Xenotransplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer KovalcikRowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Sheetal MohantyRowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Mairead HigginsRowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Daniel J HurstDepartment of Medical Education & Scholarship, Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.ORCID https://orcid.org/0000-0003-0592-2592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this review is to map and synthesize the existing literature regarding informed consent for porcine islet xenotransplantation for the treatment of Type 1 Diabetes.

methodsThe search was conducted in May 2025 through the following databases: PubMed, SCOPUS, EMBASE, and CINAHL. Broad search strings were used to combine the text words "islet" AND "xenotransplantation" AND "consent" or similar permutations and combinations. Peer-reviewed articles were included if they were published between January 1990 and May 2025 and written in English. The final search results were manually exported to a reference manager system (Zotero), and the PRISMA-ScR flow diagram was created to depict the data extraction process.

resultsFrom 134 sources, 7 articles met eligibility for this scoping review. Although clinical studies have been sporadically conducted, there is a lack of literature describing informed consent for islet xenotransplantation.

conclusionThis review highlighted a scarcity of scholarly discourse and published guidance on informed consent specifically in the context of islet xenotransplantation.

Indexed as

Diabetes Mellitus, Type 1Informed ConsentIslets of Langerhans TransplantationTransplantation, HeterologousAnimalsHumansSwineethicsinformed consentisletstype 1 diabetesxenotransplantation

Identifiers

PMID42501066
PMCPMC13401423

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.