Evidence map›Paper›PMID 42500938›Full record

ArticleAdvanced healthcare materials2026

MRI-Based Quantitative Evaluation of Tumor Ferroptosis Mediated by A Novel Self-Reducing Nano-Prodrug.

Shuang Liu, Hewen Li, Yuhang Ding, Dengyi Duan, Lin Cao, Kangkang Liu, Wenyi Zhang, Shifeng Cheng, Yiming Li, Yunfei Guo and 6 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shuang LiuDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Hewen LiDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Yuhang DingDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Dengyi DuanDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Lin CaoDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Kangkang LiuTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Wenyi ZhangDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Shifeng ChengDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Yiming LiDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Yunfei GuoDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Xiang QiDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Jianmin LiDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Xuening ZhangDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Jing PengDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Gang HanDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2300-5862
Yang ZhaoDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.ORCID https://orcid.org/0000-0003-4656-172X

Funding

National Natural Science Foundation of China 81872106National Natural Science Foundation of China 82170763National Natural Science Foundation of China 82272804National Natural Science Foundation of China 91959114Natural Science Foundation of Tianjin Municipality 22JCQNJC01700Science Fund for Distinguished Young Scholars of Tianjin Municipality 20JCJQJC00270Scientific and Technological Research Program of Tianjin Health Commission TJWJ2022XK015Scientific and Technological Research Program of Tianjin Municipal Education Commission 2019ZD025Scientific and Technological Research Program of Tianjin Municipal Education Commission 2025KJ048Tianjin Health Research Project TJWJ2023QN018Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-070 CYouth Talent Program of the Second Hospital of Tianjin Medical University 2024-QM-09
6 · The paper itself

Abstract

Ferroptosis is triggered by iron-dependent lipid peroxidation, which shows great potential in tumor therapy. However, its biomedical applications are constrained by suboptimal therapeutic efficacy, leakage of metal ions from inducing agents, and the absence of noninvasive evaluation methods. In this study, we aimed to develop a self-reducing nano-theranostic agent (Fe@AP-SAS/RGD, FASR) for tumor-targeted ferroptosis therapy and conducted real-time magnetic resonance imaging(MRI) to monitor ferroptosis by encapsulating iron oxide particles in natural apple pectin (AP). In a weakly acidic tumor microenvironment, the strong reducing ability of AP accelerated the transformation of Fe

Indexed as

FerroptosisMagnetic Resonance ImagingNanoparticlesAnimalsAntineoplastic AgentsCell Line, TumorFerric CompoundsHumansMaleMicePectinsAntineoplastic AgentsFerric CompoundsPectinsapple pectinferroptosisiron oxideMRI evaluationnano‐prodrug

Identifiers

PMID42500938
PMCPMC13507583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.