ArticleAdvanced healthcare materials2026
Gentamicin-Linked Supramolecular Hybrid Hydrogels: Mechanically Robust Cucurbit[7]Uril-Based Networks for Prolonged Infection Control.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Burn wound infections, caused by Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), remain a major clinical challenge, delaying healing and increasing the risk of mortality. Gentamicin sulfate (GEN) is a broad-spectrum antibiotic widely used for infection control. However, conventional GEN-loaded hydrogels often suffer from burst release and inadequate mechanical strength for sustained wound coverage. Here, we report GEN-loaded (0.11-0.72 w/v%) supramolecular hybrid hydrogels (GEN-SHHs) in which GEN acts in a dual role as both an antimicrobial and a dynamic physical crosslinker through cucurbit[7]uril (CB[7]) host-guest interactions within a clay-reinforced hydrogel network. This polymer network gels within 5 s and achieves an exceptional elastic modulus (up to ∼270 kPa), the highest reported for CB[7]-based or antibiotic-crosslinked hydrogels. This integrated design achieves sustained GEN release for 14 days at concentrations above the minimum inhibitory and bactericidal thresholds for S. aureus and P. aeruginosa, yielding complete eradication (>99.999%) at GEN loadings ≥0.44 w/v%. Prolonged antimicrobial efficacy is further confirmed by persistent inhibition zones over two weeks. GEN-SHHs also maintain high cytocompatibility (>94% viability) with human dermal fibroblasts (HDFs) and epidermal keratinocytes (HEKs). These results establish GEN‑SHHs combining dynamic bonding, high stiffness, and durable antimicrobial performance for advanced infection-resistant wound dressings.
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