ArticleCureus2026
Pulmonary Tumor Thrombotic Microangiopathy Diagnosed by Right Heart Catheterization in a Patient With Breast Cancer: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Pulmonary tumor thrombotic microangiopathy (PTTM) is a severe complication of malignancy, characterized by rapidly progressive pulmonary hypertension and a dismal prognosis. This report describes the case of a 71-year-old woman with a history of estrogen receptor (ER)-positive left breast cancer who developed PTTM. She presented with exertional dyspnea and a cough. Arterial blood gas analysis revealed hypoxemia with an elevated alveolar-arterial oxygen gradient. Chest computed tomography (CT) showed diffuse ground-glass and nodular opacities without obvious pulmonary embolism (PE). Echocardiography revealed right ventricular enlargement and moderate pulmonary hypertension. Right heart catheterization confirmed severe pulmonary hypertension with a mean pulmonary artery pressure of 46 mmHg and pulmonary vascular resistance of 844 dynes/sec/cm⁵. After transbronchial lung biopsy (TBLB) and bronchoalveolar lavage (BAL) failed to yield a diagnosis, PTTM was confirmed by detecting malignant cells via cytology of blood aspirated from the pulmonary artery during catheterization. The administration of systemic chemotherapy resulted in a marked improvement in hemodynamics, radiological findings, and symptoms, allowing her to be weaned from home oxygen therapy.
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