ArticleSmart molecules : open access2026
A lysosomal escape-enabled endoplasmic reticulum-targeting BODIPY photothermal agent for enhanced tumor ablation.
Article in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Photothermal therapy (PTT) has emerged as a promising minimally invasive strategy for tumor treatment due to its high selectivity, minimal drug resistance, and precise controllability. However, the efficacy of PTT is often limited by the inability of photothermal agents (PTAs) to effectively target subcellular organelles after cellular uptake. In this study, we designed and synthesized an endoplasmic reticulum (ER)-targeting BODIPY-based photothermal agent (ER-BDP) by functionalizing a trifluoromethyl-substituted BODIPY scaffold with a p-toluenesulfonyl group. The resulting ER-BDP nanoparticles (ER-BDP NPs), co-assembled with DSPE-PEG
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