ArticleSmart molecules : open access2026
Enhanced through-bond energy transfer-based bioorthogonal probe enables catalytic-amplified and sensitive detection of microRNA-21 for clinical lung cancer diagnosis.
Article in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The dysregulation of microRNA (miRNA) expression is closely linked to the pathogenesis of lung cancer, rendering the quantification of trace miRNAs clinically indispensable. However, achieving ultrasensitive detection of miRNAs in complex biological matrices, including living cells, tissues, and blood serum, remains significant challenges. To address this, we developed a fluorogenic detection platform for miR-21 based on tetrazine-mediated transfer (TMT) reactions. While TMT strategies have been previously explored, we report a refined probe design optimized through computational screening. By minimizing the energy gap (Δ
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