Evidence map›Paper›PMID 42500678›Full record

ArticleFrontiers in immunology2026

Epstein-Barr virus reactivation triggers selective IL-6/IL-10 axis inflammation and CD3

Yong Chen, Jie Wang, Qiuju Yao, Junhui Zhong, Jin Cao, Lei Du, Lipeng Shi, Chenghu Wang, Yi Ren

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yong Chen *Department of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Jie Wang *Department of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Qiuju YaoDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Junhui ZhongDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Jin CaoDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Lei DuDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Lipeng ShiDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Chenghu WangDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Yi RenDepartment of Classical Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactivation of Epstein-Barr virus (EBV) can lead to life-threatening complications beyond hemophagocytic lymphohistiocytosis (HLH). We report a case of severe EBV reactivation in a 24-year-old female. She had persistent high fever, severe leukopenia, hyperinflammatory shock, and myocardial injury, but lacked typical HLH features. Laboratory tests showed elevated proportions of CD3

Indexed as

Epstein-Barr Virus InfectionsHeart InjuriesHerpesvirus 4, HumanLeukopeniaLymphocyte ActivationVirus ActivationCD8-Positive T-LymphocytesFemaleHumansInflammationInterleukin-10Interleukin-6Young AdultIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6CD3+CD8+ T cellsEpstein-Barr virus reactivationhyperinflammatory shockIL-6/IL-10 axismyocardial injurysevere leukopenia

Identifiers

PMID42500678
PMCPMC13395857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.