ArticleFrontiers in immunology2026
Cortisol-CX
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psychological distress may be associated with systemic immune regulation through neuroendocrine-immune pathways. Emergency medical services (EMS) personnel represent a high-demand occupational group, but their circulating cytokine and chemokine profiles and their relationship with psychological distress remain poorly characterized. This exploratory cross-sectional study examined inflammatory and physiological markers in EMS personnel compared with matched controls, with particular attention to the association between cortisol and CX Methods: Seventy-eight participants, including 39 EMS personnel and 39 matched controls, underwent assessment of blood pressure, plasma cortisol, cytokines, chemokines, soluble adhesion molecules, and an exploratory panel of cardiovascular-related proteins. Psychological distress, including depression, anxiety, and stress symptoms, was assessed using the Depression, Anxiety and Stress Scale-21 in EMS personnel. Plasma concentrations of inflammatory mediators were analyzed after log10 transformation using two-way analysis of variance with group and sex as fixed factors. Spearman correlation analyses were used to explore associations between cortisol and inflammatory mediators. Results: The EMS group showed higher systolic blood pressure and cortisol levels than the control group. The EMS group also exhibited a broad cytokine-chemokine alteration characterized by increased concentrations of several cytokines, including GM-CSF, IFN-α, IL-1α, IL-1β, IL-6, IL-10, and IL-13, and chemokines, including CCL2 and CX Conclusion: EMS personnel exhibited an altered systemic cytokine-chemokine profile together with physiological changes and exploratory sex-related patterns. The selective association between cortisol and CX
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.