Evidence map›Paper›PMID 42500603›Full record

ArticleMatrix biology plus2026

Extracellular matrix abnormalities in Hutchinson-Gilford progeria fibroblasts: a specific defect in collagen IV and basement membrane architecture?

Shreya Karmacharya, Arthur Lauri Pasanen-Zentz, Franziska Busse, Nils Michael Kronenberg, Diego Rodrigo Alvarez Chavez, Suzan Al-Gburi, Tristan Lerbs, Bent Brachvogel, Clara Velmans, Iliana Tantcheva-Poor and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shreya KarmacharyaCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Arthur Lauri Pasanen-ZentzCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Franziska BusseDepartment of Chemistry and Biochemistry, Humboldt Centre for Nano- and Biophotonics, University of Cologne, Cologne, Germany.
Nils Michael KronenbergDepartment of Chemistry and Biochemistry, Humboldt Centre for Nano- and Biophotonics, University of Cologne, Cologne, Germany.
Diego Rodrigo Alvarez ChavezTranslational Matrix Biology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Suzan Al-GburiTranslational Matrix Biology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Tristan LerbsInstitut für Allgemeine Pathologie und Pathologische Anatomie, Faculty of Medicine, University of Cologne, Cologne, Germany.
Bent BrachvogelCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Clara VelmansInstitute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
Iliana Tantcheva-PoorDepartment of Dermatology and Venereology, Medical Faculty and University Hospital of the University of Cologne, Cologne, Germany.
Raimund WagenerCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Mats PaulssonCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Carien M NiessenDepartment Cell Biology of the Skin, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Malte Christian GatherDepartment of Chemistry and Biochemistry, Humboldt Centre for Nano- and Biophotonics, University of Cologne, Cologne, Germany.
Thomas KriegTranslational Matrix Biology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Alvise SchiavinatoCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hutchinson-Gilford progeria (HGPS) is a rare genetic disorder characterized by clinical features that mimic accelerated aging. The classical form of progeria is caused by a heterozygous pathogenic variant in in the

Indexed as

Basement membraneCollagen IVProgeria

Identifiers

PMID42500603
PMCPMC13396937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.