Evidence map›Paper›PMID 42500553›Full record

ArticleBrain communications2026

The ILLUMINATE natural history study in colony-stimulating factor 1 receptor-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

David S Lynch, Charles Wade, Ludger Schöls, Stefanie N Hayer, Jeffrey M Gelfand, Wolfgang Köhler, Christa-Caroline Bergner, Paulo Victor Sgobbi de Souza, Elizabeth C Finger, Nicole I Wolf and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

David S LynchDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and NIHR University College London Hospitals Biomedical Research Centre, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-0615-7159
Charles WadeQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London WC1B 5EH, UK.
Ludger SchölsDepartment of Neurology, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Tübingen University Hospital, Tübingen 72076, Germany.ORCID https://orcid.org/0000-0001-7774-5025
Stefanie N HayerDepartment of Neurology, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Tübingen University Hospital, Tübingen 72076, Germany.
Jeffrey M GelfandUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Wolfgang KöhlerDepartment of Neurology, University of Leipzig Medical Centre, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-6058-9545
Christa-Caroline BergnerDepartment of Neurology, University of Leipzig Medical Centre, Leipzig 04103, Germany.
Paulo Victor Sgobbi de SouzaDepartment of Neurology and Neurosurgery, PSEG Centro de Pesquisa Clínica, São Paulo, SP 04.038-002, Brazil.
Elizabeth C FingerClinical Neurological Sciences, Western University, London, ON N6A 3K7, Canada.ORCID https://orcid.org/0000-0003-4461-7427
Nicole I WolfAmsterdam Leukodystrophy Center, Department of Child Neurology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam and Amsterdam Neuroscience, Amsterdam 1081 HV, the Netherlands.ORCID https://orcid.org/0000-0003-1721-0728
Shanice BeerepootAmsterdam Leukodystrophy Center, Department of Child Neurology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam and Amsterdam Neuroscience, Amsterdam 1081 HV, the Netherlands.ORCID https://orcid.org/0000-0003-2945-6784
Jennifer L Orthmann-MurphyDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tomasz ChmielaDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.
Raj RajagovindanFormerly Vigil Neuroscience, Inc., Watertown, MA 02472, USA.
Donald G McLarenVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Francois GaudreaultVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Christian MirescuVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Denitza RaitchevaVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Andreas MeierFormerly Vigil Neuroscience, Inc., Watertown, MA 02472, USA.
David GrayVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Juan ChavezVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Petra KaufmannVigil Neuroscience, Inc., Watertown, MA 02472, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colony-stimulating factor 1 receptor-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP) is a rare, fatal, autosomal-dominant neurodegenerative disorder caused by pathogenic

Indexed as

CSF1R-related leukoencephalopathyhereditary diffuse leukoencephalopathy with spheroidsleukodystrophymagnetic resonance imagingprimary microgliopathy

Identifiers

PMID42500553
PMCPMC13397125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.