ArticleFrontiers in medicine2026
Case Report: First report of blue-green neutrophilic inclusions in Epstein-Barr virus-related hemophagocytic lymphohistiocytosis: a fatal pediatric case and literature review.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Green neutrophilic inclusions (GNIs) are rare cytoplasmic inclusions in peripheral blood smears, historically associated with acute liver failure and high mortality. Recent evidence suggests that GNIs may also occur in other critical illnesses; however, reports in pediatric populations remain scarce. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome, but GNIs have not been previously described in patients with HLH. Case presentation: We report a 9-year-and-5-month-old female with Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH) in whom GNIs were identified in peripheral blood neutrophils during her clinical course. The patient presented with persistent fever, progressive cytopenias, hyperferritinemia, hemophagocytosis on bone marrow aspirate, and markedly elevated cytokines. Despite intensive supportive care, including continuous renal replacement therapy and plasma exchange, her condition deteriorated rapidly. On hospital day 6, GNIs were identified in her peripheral blood neutrophils. She died of multiorgan dysfunction on hospital day 8. Conclusion: This is the first report of GNIs in a patient with EBV-HLH. GNIs expand the clinical spectrum of EBV-HLH and may serve as an ominous prognostic marker in pediatric patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.