ArticleFrontiers in medicine2026
Evaluation of pre-dilution combined with optical/fluorescent platelet counting for correcting pseudothrombocytopenia.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Pseudothrombocytopenia (PTCP), a common artifact in hematology, often leads to misdiagnosis and unnecessary interventions, with EDTA-dependent PTCP being the most frequent. Current corrective methods are limited by inefficiency and the risk of recurrence. Methods: This study evaluated an integrated strategy-1:7 pre-dilution of fresh EDTA blood with optical/fluorescent platelet counting (PLT-O/PLT-F)-to correct PTCP caused by various factors. A total of 21 PTCP samples were analyzed using the impedance platelet counting method (PLT-I), conventional PLT-O/PLT-F, and pre-diluted PLT-O/PLT-F modes on Mindray BC-7500 CS and Sysmex XN20 analyzers, with manual counting (PLT-M) as the reference. Assessments included anti-interference efficacy: aggregation interference rejection (AIR), outlier rate (OR), and accuracy: recovery rate (RR), mean bias rate (MBR), root mean square error (RMSE), non-parametric bias analysis, and correlation/agreement tests. Results: Pre-dilution significantly improved anti-interference: DIL BC7500 PLT-O showed the highest AIR (95.24%) and the lowest OR (19.05%). Conventional modes showed significant negative bias, while pre-diluted modes eliminated bias, with RR within an acceptable range (90-110%) and low RMSE (23.15%). Non-parametric analysis showed no significant difference between DIL PLT-O/F and PLT-M ( Discussion: Study limitations include a small sample size, single-center data, and testing only two analyzers. In conclusion, 1:7 pre-dilution with PLT-O/PLT-F effectively reduces platelet aggregation in PTCP, improves accuracy, anti-interference, and consistency, and offers a pilot solution for laboratory PTCP management. Further multicenter, large-scale studies are needed for validation.
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