Evidence map›Paper›PMID 42500514›Full record

ArticleFrontiers in medicine2026

Genetic testing and reproductive decision-making in Chinese families with inherited retinal disease: a cross-sectional study.

Victoria Y Gu, Jingli Guo, Xuerui Zhang, Wenting Zhang, Huanyu Liu, Haodong Xiao, Dian Jiao, Jiawei Yin, Tian Tian, Peiquan Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria Y GuGeorgetown University School of Medicine, Washington, DC, United States.
Jingli GuoDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuerui ZhangDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenting ZhangDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huanyu LiuDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haodong XiaoDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dian JiaoDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiawei YinDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tian TianDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peiquan ZhaoDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify variables associated with parental willingness toward genetic testing (GT) and subsequent reproductive (SR) intentions via natural conception (NC) or assisted reproductive technology (ART) among Chinese families with inherited retinal diseases (IRDs). Methods: Cross-sectional study of 136 children with IRDs and their biological parents at two academic referral centers in Shanghai, China (September 2023 to March 2024). Parents were surveyed on demographics, clinical characteristics, parent-reported outcome measures (ROMs) for psychosocial and economic burden, and willingness toward GT and SR. Formal genetic counseling was not available at participating centers. Results: Among 136 children [mean (SD) age, 7.10 (4.32) years; 50 (36.8%) female and their parents [mean (SD) age, 34.4 (5.8) years; 84 (61.8%) mothers], 72.1% had or were willing to undergo GT. GT willingness was positively associated with child age under 12 (OR, 1.61; Conclusion: Parental GT and SR decision-making was shaped by clinical and psychosocial factors, underscoring the need for genetic counseling at IRD referral centers.

Indexed as

assisted reproductive technologygenetic counselinggenetic testinginherited retinal diseasereproductive ophthalmology

Identifiers

PMID42500514
PMCPMC13395770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.