ArticleFrontiers in veterinary science2026
Protective effects of chlorogenic acid against LPS-induced intestinal oxidative injury in mice via activation of the PI3K/Akt-Nrf2/HO-1 signaling axis.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oxidative stress is a key pathological cause of intestinal epithelial injury and related intestinal diseases. Chlorogenic acid (CGA), a natural polyphenol, has notable antioxidant activity. This study explored the multi-target protective effects of CGA on intestinal epithelial cells and mouse intestinal tissue against oxidative injury, as well as its underlying molecular mechanisms. Methods: Network pharmacology was applied to screen core targets and enriched pathways of CGA against oxidative stress. H₂O₂-induced MODE-K cell oxidative damage model and LPS-induced mouse intestinal injury model were constructed. CCK-8, biochemical detection, qPCR, molecular docking, Western blotting and histopathological assay were performed to verify the protective effects and related signaling pathways. Results: Network pharmacology predicted PI3K/Akt and Nrf2/HO-1 pathways as crucial targets. Conclusion: CGA exerts multi-target antioxidant and intestinal protective effects by inhibiting Keap1-Nrf2 interaction and activating PI3K/Akt-Nrf2/HO-1 signaling axis, mitigating intestinal oxidative injury. Our findings provide a mechanistic basis for the application of CGA as a functional food ingredient or dietary intervention to alleviate intestinal oxidative stress in livestock.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.