ArticleJournal of International Society of Preventive & Community Dentistry
Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study.
Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: Early childhood caries (ECC) is a multifactorial disease driven by biological and psychosocial determinants. Identifying noninvasive biomarkers could improve risk stratification and personalized prevention. The aim of the study is to evaluate the association of salivary cortisol, total secretory immunoglobulin A (sIgA), and pro-inflammatory cytokines (interleukin-6 [IL-6], interleukin-1β [IL-1β], and tumor necrosis factor-alpha [TNF-α]) with ECC in preschool children.IL-1β. Mathods: This cross-sectional analytical study included 120 children aged 3-6 years (60 ECC; 60 caries-free). Unstimulated saliva was collected via passive drooling. Biomarkers were quantified using high-sensitivity enzyme-linked immunosorbent assay kits. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed, adjusting for age, sex, feeding practices, oral hygiene, and socioeconomic status (SES). Results: Children with ECC exhibited significantly higher levels of salivary cortisol (8.92 + -2.11 vs. 5.21 + -1.98 ng/mL, Conclusion: Salivary cortisol, sIgA, and inflammatory cytokines are significantly associated with ECC, reflecting complex interactions between stress physiology, mucosal immunity, and oral dysbiosis. While these biomarkers show promise as early-warning indicators, longitudinal data are required to establish their discriminatory utility for caries onset.
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