ArticleFrontiers in oncology2026
Icaritin inhibits breast cancer through activating MT1X to promote ferroptosis and synergizing with NF-κB pathway suppression.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Icaritin (ICT) is a natural isoprenylated flavonoid compound extracted from the traditional Chinese herbal medicine Methods: Results: ICT induced ferroptosis and suppressed viability in breast cancer cells, as evidenced by intracellular Fe Discussion: This study elucidates that ICT exerts anti-breast cancer effects by activating MT1X to induce ferroptosis and cooperatively inhibit the NF-κB signaling pathway. Our findings reveal a novel molecular mechanism of ICT against breast cancer, and provide a new therapeutic target and experimental basis for breast cancer treatment.
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