ArticleFrontiers in nutrition2026
Asiatic acid from
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Introduction: Chronic kidney disease (CKD) is a progressive condition characterized by renal fibrosis, with limited therapeutic options. Asiatic acid (AA), a triterpenoid from Methods: An adenine-induced CKD mouse model was established in C57BL/6 mice. AA was administered orally at 10 or 30 mg/kg for 8 weeks. Antibiotic depletion experiments were performed to assess gut microbiota dependence. Renal function, histopathology, and fibrosis markers were evaluated. Multi-omics analyses integrated 16S rRNA sequencing, renal untargeted metabolomics, transcriptomics, and MetOrigin-based tracing. Results: AA significantly improved renal function, reduced tubular injury and collagen deposition, and restored gut barrier integrity. Antibiotic depletion experiments demonstrated that an intact gut microbiota is required for the renoprotective effects of AA supporting a functional link along the gut-kidney axis. AA remodeled the gut microbiota, notably enriching Discussion: AA alleviates CKD in association with remodeling of the gut microbiota and reprogramming of renal retinol metabolism, supporting its potential as a dietary supplement for countering renal fibrosis and supporting kidney health.
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