Evidence map›Paper›PMID 42500245›Full record

ArticleFrontiers in nutrition2026

Specific carbohydrate diet versus Mediterranean diet in adult patients with mild to moderate ulcerative colitis: a randomized controlled-feeding trial.

Albert Sheng-Yin Chen, Long H Nguyen, Brianna Gray, Katherine Williams, Jenny Gurung, Lauren Canha, Jessica McGoldrick, Jane Hubbard, Hamed Khalili

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04398550 (Specific Carbohydrate Diet vs. Mediterranean Diet Therapy in Ulcerative Colitis - A Clinical Trial), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04398550 naunknown statusnot on this map

Specific Carbohydrate Diet vs. Mediterranean Diet Therapy in Ulcerative Colitis - A Clinical Trial

TypeinterventionalSponsorMassachusetts General HospitalRan2020 to 2023Enrolled50ConditionsUlcerative ColitisArmsSpecific Carbohydrate Diet, Mediterranean Diet
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Albert Sheng-Yin Chen *Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Long H Nguyen *Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Brianna GrayTranslational and Clinical Research Centers, Massachusetts General Hospital, Boston, MA, United States.
Katherine WilliamsDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jenny GurungDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Lauren CanhaDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jessica McGoldrickDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jane HubbardTranslational and Clinical Research Centers, Massachusetts General Hospital, Boston, MA, United States.
Hamed KhaliliClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: This pilot randomized controlled-feeding trial compared the effect of Specific Carbohydrate Diet (SCD) and Mediterranean diet (MeD) in mild to moderate ulcerative colitis (UC). Methods: Seventeen adults were randomized to a 6-week SCD ( Results: The study was discontinued early due to significant dropout ( Conclusion: In this pilot trial, SCD and MeD showed no difference in therapeutic effects for patients with mild to moderate UC. However, the study was limited by a significant drop out in both arms. Clinical trial registration: ClinicalTrials.gov, identifier NCT04398550.

Indexed as

mediterranean dietmicrobiomerandomized controlled trialspecific carbohydrate dietulcerative colitis

Identifiers

PMID42500245
PMCPMC13395713

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.