ArticleFrontiers in endocrinology2026
Serum and serum-derived extracellular vesicle microRNA signatures linked to neurodevelopmental processes in central precocious puberty.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal (HPG) axis. While hormonal mechanisms underlying pubertal initiation are well established, the molecular regulatory processes accompanying altered pubertal timing remain incompletely understood. Circulating microRNAs (miRNAs), detectable either freely or within extracellular vesicles (EVs), represent a molecular layer of post-transcriptional regulation associated with pubertal development. Methods: Serum samples from female patients diagnosed with CPP and age-matched healthy female controls were analyzed by small RNA sequencing to identify differentially expressed miRNAs. Selected miRNAs were validated by quantitative real-time PCR (RT-qPCR) in an expanded cohort using serum RNA and RNA isolated from serum-derived EVs. Functional enrichment analysis was conducted using experimentally validated miRNA target genes. Results: Small RNA sequencing identified ten miRNAs with significantly altered expression levels in CPP (adjusted p-value < 0.05, |log Conclusions: This study provides a comprehensive analysis of the circulating miRNA profile in female patients with CPP. The coordinated alteration of freely circulating and EV-associated miRNAs highlight the potential contribution of miRNA-mediated regulation to premature HPG axis activation and provides a framework for further investigation of the molecular mechanisms underlying pubertal disorders.
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