ArticleWorld journal of otorhinolaryngology - head and neck surgery2026
ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration.
Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration.World journal of otorhinolaryngology - head and neck surgery · 2026Article
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6 authors.
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Abstract
Objectives: Angiopoietin-2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated. Methods: An integrative analysis using multiple public databases was conducted to evaluate the expression pattern, prognostic value, and potential functional pathways associated with ANGPT2 in THCA. Experimental validation was performed using human THCA tissues and TPC-1 cell lines. Quantitative PCR, Western blotting, and multiplex immunofluorescence were used to assess ANGPT2 expression and its correlation with immune infiltration. Stable ANGPT2-overexpressing TPC-1 cells were constructed, and functional assays, including CCK-8, wound healing assay, and Western blotting, were employed to evaluate proliferation and migration. Results: ANGPT2 was significantly upregulated in THCA tissues compared with normal thyroid tissues (median transcript per million: 3.29 vs 3.13, Conclusions: ANGPT2 promoted thyroid cancer cell proliferation and migration through activation of the PI3K/AKT signaling pathway, and was closely linked to altered immune cell infiltration. Its overexpression was associated with unfavorable prognosis, underscoring its potential as both a prognostic biomarker and a therapeutic target in thyroid cancer.
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