ArticleWorld journal of otorhinolaryngology - head and neck surgery2025
Distinct Nasal Microbiome Profiles and Prediction Model for Allergic Rhinitis, Nonallergic Rhinitis, and Healthy Children.
Article in World journal of otorhinolaryngology - head and neck surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Adult studies reported differences in nasal microbiota composition among patients with allergic rhinitis (AR), nonallergic rhinitis (NAR), and healthy controls (HCs), whereas pediatric data remain limited. This study compared the nasal microbiomes of children with AR, NAR, and HC, investigated factors influencing these microbiomes, and developed a predictive model to differentiate these conditions based on microbiome data. Methods: Nasal swab samples were collected from children with AR, NAR, and HC. Microbial characterization was performed using 16S rDNA sequencing to analyze bacterial composition. Relevant demographic data and influencing factors were collected. Results: Sixty participants (median age 6.3 [4.3-8.4] years, 51.6% males) were categorized into AR ( Conclusion: This pilot study identified preliminary differences in nasal microbiome diversity and composition among children with AR, NAR, and HC. Differential microbial abundances may reflect distinct rhinitis phenotypes. However, these findings are hypothesis-generating and require validation in larger, independent cohorts.
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