Evidence map›Paper›PMID 42500049›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2026

Neuroendocrine Carcinoma of the Head and Neck: A Two-Decade Institutional Experience.

Micah K Harris, Katie M Carlson, Nathan Lu, Anthony Tang, Matthew E Spector, Joshua D Smith, Jessica H Maxwell, Kevin J Contrera, Seungwon Kim, Steven B Chinn and 2 more

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In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Micah K HarrisDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0009-0004-5036-8919
Katie M CarlsonDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Nathan LuDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Anthony TangDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Matthew E SpectorDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Joshua D SmithDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Jessica H MaxwellDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Kevin J ContreraDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Seungwon KimDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Steven B ChinnDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Angela MazulDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.
Shaum S SridharanDepartment of Otolaryngology-Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Primary neuroendocrine carcinoma (NEC) of the head and neck is rare (< 1% of cases) and aggressive, with poorly defined management strategies. This study evaluated clinical characteristics, treatment patterns, and survival outcomes in a single-institution cohort, identifying factors associated with improved survival. Methods: A retrospective review was conducted of patients with head and neck NEC treated at a tertiary center. Variables associated with 3-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were assessed using Cox regression and Kaplan-Meier curve analyses. Results: Sixty-nine patients (59.4% male, 95.7% White) were included. The most common subsites were sinonasal (36.2%) and laryngeal (30.4%). Most tumors were poorly differentiated (73.9%), and 50.7% were T category 3-4. Surgical resection was performed in 68.1% and primary radiotherapy or chemoradiotherapy in 20.3% of patients. Overall 3-year OS and RFS were 55.5% and 56.1%, respectively. On multivariable analysis, surgery remained associated with improved 3-year OS (adjusted hazard ratio [aHR]: 0.21, 95% CI: 0.06-0.66, Conclusions: Head and neck NEC carries a poor prognosis. Undergoing surgical resection was strongly associated with improved 3-year OS and DSS in our cohort, highlighting its importance when feasible. Multicenter collaboration and prospective studies are warranted to refine optimal treatment strategies for this rare and challenging malignancy.

Indexed as

cancerhead and neckmanagementneuroendocrine

Identifiers

PMID42500049
PMCPMC13398568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.