Evidence map›Paper›PMID 42500035›Full record

ArticleACS central science2026

Targeted Transcriptional Repression by Induced Proximity.

Christian E Stieger, Xinru Chen, Christina C Kuismi, Dustin Dovala, Daniel Fuller, Andreas O Frank, Mikias Woldegiorgis, Megan Bruce-Smythe, Fabian Wu, Nicolas Pizzato and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Christian E StiegerDepartments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0001-5829-2307
Xinru ChenDepartments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.
Christina C KuismiDepartments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.ORCID https://orcid.org/0009-0002-5016-7733
Dustin DovalaNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.ORCID https://orcid.org/0000-0002-2278-5027
Daniel FullerNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Andreas O FrankNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.ORCID https://orcid.org/0000-0002-2330-3974
Mikias WoldegiorgisNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Megan Bruce-SmytheNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Fabian WuNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Nicolas PizzatoNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Jeffrey McKennaNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Cory JohannessenNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Barna D FodorNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.
Markus SchirleNovartis-Berkeley Translational Chemical Biology Institute, Berkeley, California, 94720, United States.ORCID https://orcid.org/0000-0003-4933-2623
Daniel K NomuraDepartments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0003-1614-8360

Funding

Tackling Undruggable Cancer Targets using Chemoproteomic PlatformsR35CA263814 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Daniel Nomura · 2022 to 2026
$4.6M
Harnessing E3 Ligases for Cancer TherapyR01CA240981 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Daniel Nomura · 2019 to 2026
$4.3M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NCI NIH HHS R01 CA240981NCI NIH HHS R35 CA263814NIH HHS S10 OD024998
6 · The paper itself

Abstract

Many transcription factors are considered "undruggable" and challenging targets due to the absence of ligandable pockets, large swaths of intrinsically disordered regions, and rapid turnover. Here, we describe a new induced-proximity therapeutic modality,

Identifiers

PMID42500035
PMCPMC13397437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.